Pregnenolone works with your body to achieve optimal health and
longevity and is one of the most important hormones in the human body. Pregnenolone
helps reduce fatigue and increase endurance as well as providing the brain with
the hormonal and neurotransmitter support it needs to retard memory loss.
Pregnenolone is often referred to as the grandparent precursor
to steroid hormones in mammals. Pregnenolone is synthesized from
cholesterol in the mitochondria of adrenal glands and to lesser extent in the brain, liver, skin, testes and ovaries.
Once synthesized, pregnenolone is released from the mitochondria into
the cytosol where it can be converted to DHEA (dehydroepiandrosterone)
or to progesterone.
DHEA serves as a precursor compound to the androgens
and the estrogens through androstenedione as the intermediate compound.
Progesterone is the precursor to cortisol, aldosterone,
androstenedione, estrogen, and testosterone. Pregnenolone may also be
secreted directly into the blood where it circulates primarily as the
sulfated form. Pregnenolone has many actions of its own not attributable
to its conversion to progesterone or to DHEA.
Recent studies show that Pregnenolone is important for the function of brain, nervous tissue,
liver, pancreas, reproductive tissues, pituitary and skin. Pregnenolone
is found in higher concentrations in the central nervous system compared
to the peripheral tissues which may reflect its importance in brain
As with many hormones, pregnenolone production declines with
age. It is estimated that pregnenolone production is about 60% less at
age 75 than at age 35. Pregnenolone levels may also decline under
various conditions of physiological stress, such as acute and chronic
infections and trauma.
Pregnenolone is the building block for all other steroid hormones. It may also provide supportive anti-stress benefits.
levels dramatically drop after age 30. Research indicates that
restoration of pregnenolone to levels of healthy young adults may
provide support for memory, mood and energy.
Recommended Use: Adults:
take 1/2 to 1 tablet daily as directed by your healthcare professional
ONLY! Allow tablet to dissolve in mouth and then swallow.
Warning: NOT TO BE TAKEN BY INDIVIDUALS UNDER THE AGE OF 18. DO NOT USE IF
PREGNANT OR LACTATING. Consult a physician or licensed qualified
healthcare professional before using this product if you have or have a
family history of breast cancer, uterine cancer, prostate cancer or
enlargement, heart disease, low HDL cholesterol (good cholesterol), or
if you are using any other dietary supplement, prescription drug, or
over-the-counter drug. Do not exceed the recommended serving.
Exceeding the recommended serving may cause serious adverse side
effects. If you are at risk for or have prostate, breast, uterine or
ovarian cancer you should not use this product. If you are pregnant,
nursing or taking any prescription medication, especially other hormones
or MAOIs (Monoamine Oxidase Inhibitors) consult with your physician
before using this product. Possible side effects include changes in
liver function, acne, hair loss, hair growth on face (women),
aggressiveness, irritability, and increased levels of estrogen.
Discontinue use and call a physician or licensed qualified healthcare
professional immediately if you experience rapid heartbeat, dizziness,
blurred vision, or other similar symptoms. Keep out of the reach of
SUGGESTED USE: Please consult your physician
before using this product. As a dietary supplement, take ½ to 1 tablet
daily, or as directed by physician. Take sublingually by dissolving in
mouth, or water or juice.