Bauhika with Bauhinia Leaf Extract to
Normalize Glucose. Currently, there is no method to prevent or cure
diabetes. The disease may only be moderately controlled with conventional
methods. As a result, a growing number of individuals are looking to dietary
supplements to help manage their disease.
This is where Bauhika can be of great help! Bauhinia extract, Bauhika, has been
used in Brazil by naturopaths to successfully manage diabetes for decades
without any side effects or potential health risks. Type 2 diabetes can be
successfully managed through the regular, day-to-day use of Bauhika
Bauhinia Natural Extract Scientists who have studied and quantified the
constituents of Bauhika determined the plant leaves contained a well-known
chemical called astragalin as well as flavonoids, alkaloids and glycosides.
Overall this chemical has been reported to help repair kidney cell damage, and
to have a diuretic effect.
The main plant chemicals include astragalin, bauhinoside, beta-siderol,
flavonols, flavonoids, glycosides, guanidine, heteroglycosides, kaempferitrin,
organic acids, quercitrosides, rhamnose and saponins. Considering all the
natural contents, this makes Bauhika an antidiabetic, hypoglycemic,
tonic (tones, balances and strengthens over all body functions),
hypocholesteromic (lowers cholesterol), antimalarial, antifungal,
anti-inflammatory, hepatoprotective (liver protection), analgesic, diuretic,
uterine relaxant, blood cleanser.
Bauhika contains only cultivated Bauhinia
extract. Bauhinia is a tree, which grows exclusively in the tropical jungles and
results within 3-6 weeks
Bauhinia Extract Clinical Studies
The leaves of green plants as well as a cyanobacterium, a red alga, and fungi contain insulin-like antigens.
Silva LB, Santos SS, Azevedo CR, Cruz MA, Venâncio TM, Cavalcante CP, Uchôa AF, Astolfi Filho S, Oliveira AE, Fernandes KV, Xavier-Filho J.
Laboratório de Química e Função de Proteínas e Peptídeos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense, Campos dos Goytacazes, RJ, Brasil.
We report the detection of insulin-like antigens in a large range of species utilizing a modified ELISA plate assay and Western blotting. We tested the leaves or aerial parts of species of Rhodophyta (red alga), Bryophyta (mosses), Psilophyta (whisk ferns), Lycopodophyta (club mosses), Sphenopsida (horsetails), gymnosperms, and angiosperms, including monocots and dicots. We also studied species of fungi and a cyanobacterium, Spirulina maxima. The wide distribution of insulin-like antigens, which in some cases present the same electrophoretic mobility as bovine insulin, together with results recently published by us on the amino acid sequence of an insulin isolated from the seed coat of jack bean (Canavalia ensiformis) and from the developing fruits of cowpea (Vigna unguiculata), suggests that pathways depending on this hormone have been conserved through evolution.
PMID: 11887207 [PubMed - indexed for MEDLINE]
Bauhinia candicans stimulation of glucose uptake in isolated gastric glands of normal and diabetic rabbits.
Fuentes O, Alarcón J.
Laboratorio de Fisiología, Facultad de Ciencias, Universidad del Bío-Bío, Campus Chillán, Avenida Andrés Bello s/n, P.O. Box 447, Chillán, Chile. firstname.lastname@example.org
A butanol extract of dried leaves of Bahuinia candicans showed, in vitro, a stimulatory effect of glucose uptake in isolated gastric glands of normal and alloxan-diabetic rabbits. The extract (0.001-0.07 mg/mg protein) produced a dose-dependent effect and was similar to the effect of insulin (1-100 nM). These findings suggest that the extract contains compound(s) that efficiently increase glucose transport at the basolateral side of isolated gastric glands.
PMID: 16690222 [PubMed - indexed for MEDLINE]
Acute effect of Bauhinia forficata on serum glucose levels in normal and alloxan-induced diabetic rats.
Silva FR, Szpoganicz B, Pizzolatti MG, Willrich MA, de Sousa E.
UFSC Departamento de Bioquímica, Centro de Ciências Biológicas, Campus Universitário, Bairro Trindade, Cx Postal 5069, CEP-88040-970, SC, Florianópolis, Brazil. email@example.com
Experimental diabetes was used to study the acute effect of the n-butanol fraction of Bauhinia forficata Link (Leguminosae) (BF) leaves on the serum glucose levels of rats. Body weight was measured on the day of diabetes induction and on the day of the experiment. Levels of glucose were determined at different doses and times following treatment with BF or with vehicle in normal, diabetic and hyperglycemic normal rats. Oral administration of n-BuOH fraction led to a significant blood glucose-lowering effect in normal and diabetic rats. However, in glucose-fed hyperglycemic normal rats, the maximum dose of this fraction failed to decrease blood glucose levels. The hypoglycemic effect was observed at doses of 500 and 600 mg/kg after 1 and 2 h treatment respectively, in normal rats. The maximum effect of BF was detected at 1 h with 800 mg/kg in diabetic animals and this profile was maintained for the next 3 h. Treatment of normal and alloxan-induced diabetic rats with BF decreased glucose levels, while this fraction was devoid of hypoglycemic effect in glucose-fed hyperglycemic normal rats.
PMID: 12413705 [PubMed - indexed for MEDLINE]
Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(alpha)-dirhamnoside from Bauhinia forficata leaves.
de Sousa E, Zanatta L, Seifriz I, Creczynski-Pasa TB, Pizzolatti MG, Szpoganicz B, Silva FR.
Departamento de Química, Centro de Ciências Físicas e Matemáticas, Campus Universitário, Bairro Trindade. Cx. Postal 5069, CEP 88040-970, Florianópolis, SC, Brazil.
In vivo and in vitro treatments were carried out to investigate the effects of kaempferol-3,7-O-(alpha)-dirhamnoside (kaempferitrin), a major flavonoid compound of the n-butanol fraction from Bauhiniaforficata leaves, on serum glucose levels, as well as its antioxidant potential. Oral administration of kaempferitrin led to a significant hypoglycemic effect in normal and in alloxan-induced diabetic rats. In normal rats, blood glucose lowering was observed only with the higher dose of kaempferitrin (200 mg/kg) at 1 h after treatment. However, the hypoglycemic effect of kaempferitrin in diabetic rats was evident at all doses tested (50, 100, and 200 mg/kg), and this profile was maintained throughout the period studied for both higher doses. Additionally, in glucose-fed hyperglycemic normal rats, the kaempferitrin failed to decrease blood glucose levels. In vitro antioxidant properties or action against reactive oxygen species of this compound was also evaluated. The compound showed high reactivity with 1,1-diphenyl-2-picryl hydrazyl (DPPH), IC(50) of 84.0 +/- 7.8 microM, inhibited myeloperoxidase activity with K(0.5) = 86 +/- 9.9 microM, and decreased lipid peroxidation, induced by ascorbyl radical either in microsomes or in asolectin and phosphatidylcholine liposomes, with IC(50)'s of 320 +/- 14.1, 223 +/- 8.3, and 112 +/- 8.8 microM, respectively.
PMID: 15165145 [PubMed - indexed for MEDLINE]
Advances in research of chemical constituents and pharmacological activites of Bauhinia]
Shang XY, Liu W, Zhao CW.
Beijing Union University, Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing 100083, China. firstname.lastname@example.org
The research advances based on the related references were summarized in the last thirty years. Bauhinia contained many kinds of chemical constituents, primarily including flavanoids, steroids, terpenoid and so on, some of them were firstly obtained from the nature. Many plants of the Bauhinia are used in traditional medicine for their interesting biological activities such as antidiabetic, antiinflammatory, antimicrobial, analgesic, astringent and diuretic effects. This paper gives an overview of phytochemical and pharmacological research in Bauhinia, and it has been classified accordding to the chemical structure characteristics. To provide more material to draw on for further development and utilization resources of Bauhinia.
PMID: 18590204 [PubMed - in process]
Anti-diabetic activity of Bauhinia forficata decoction in streptozotocin-diabetic rats.
Pepato MT, Keller EH, Baviera AM, Kettelhut IC, Vendramini RC, Brunetti IL.
Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP, R Expedicionários do Brasil 1621, SP, Araraquara, Brazil. email@example.com
The effects of using Bauhinia forficata leaf decoction (150 g leaf/l water; 35.2+/-7.8 ml/100 g body weight mean daily dose) as a drinking-water substitute for about 1 month on streptozotocin-diabetes (STZ-diabetes) in male Wistar rats were investigated. The physico-metabolic parameters measured were: body weight, food and liquid intake, urinary volume, hepatic glycogen, serum triglycerides and cholesterol, plasma glucose, urinary glucose and urea, and the weight of epididymal and retroperitoneal adipose tissue and soleus and extensor digitorum longus muscles. The STZ-diabetic rats treated with decoction showed a significant reduction in serum and urinary glucose and urinary urea as compared to the STZ-diabetic control, no difference being seen between decoction-treated and -untreated non-diabetic rats. The other physico-metabolic factors showed no changes in treated STZ-diabetic rats. The improvement in carbohydrate metabolism seen in the rats treated with Bauhinia forficata decoction does not appear to be linked to the inhibition of glycogenolysis or the stimulation of glycogenesis nor does it appear to act in a way similar to insulin or the sulfonylureas, although it may act by the inhibition of neoglycogenesis in a manner similar to that of the biguanides.
PMID: 12065150 [PubMed - indexed for MEDLINE]
Clinical trial of Myrcia uniflora and Bauhinia forficata leaf extracts in normal and diabetic patients.
Russo EM, Reichelt AA, De-Sá JR, Furlanetto RP, Moisés RC, Kasamatsu TS, Chacra AR.
Disciplina de Endocrinologia, Escola Paulista de Medicina, São Paulo, Brasil.
1. Myrcia uniflora and Bauhinia forficata were compared with placebo for their hypoglycemic effect in randomized cross-over double-blind studies in 2 groups of normal subjects (10 subjects each) and 2 groups of Type II diabetic patients (18 in the M. uniflora group and 16 in the B. forficata group). The protocol with each plant lasted 56 days. 2. After the ingestion of infusions of 3 g leaves/day of M. uniflora and B. forficata leaves, no acute or chronic effects on plasma glucose levels or glycated hemoglobin were found in either group. However, plasma insulin levels in the diabetic group were lower after M. uniflora than after placebo. 3. Among other clinical parameters tested, a statistically significant difference was found only in the alkaline phosphatase level after placebo compared with that after M. uniflora in the normal group. 4. There were no differences in any clinical parameters after the use of placebo or of B. forficata. 5. We conclude that infusions prepared from the leaves of M. uniflora or B. forficata have no hypoglycemic effect on normal subjects or Type II diabetic patients.
PMID: 2201413 [PubMed - indexed for MEDLINE]
Effects of Bauhinia megalandra aqueous leaf extract on intestinal glucose absorption and uptake by enterocyte brush border membrane vesicles.
Gonzalez-Mujica F, Motta N, Márquez AH, Capote-Zulueta J.
Sección de Bioquímica Médica, Instituto de Medicina Experimental, Facultad de Medicina, Universidad Central de Venezuela, Apartado Postal 50587, Sabana Grande, Caracas, Venezuela. firstname.lastname@example.org
Aqueous extract of Bauhinia megalandra leaves was able to inhibit the intestinal glucose absorption in a concentration-dependent way and additive to phlorizine. Moreover, B. megalandra leaf extract drastically reduced the 14C-glucose uptake by enterocyte brush border membrane vesicles. The B. megalandra leaf extract administrated orally, simultaneously with glucose improved the glucose tolerance with a significant reduction of the 30-min peak. The extract did not have an effect on the glucose tolerance when glucose was administrated subcutaneously.
PMID: 12628399 [PubMed - indexed for MEDLINE
Effect of Bauhinia forficata aqueous extract on the maternal-fetal outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats.
Volpato GT, Damasceno DC, Rudge MV, Padovani CR, Calderon IM.
Laboratório de Pesquisa Experimental de Ginecologia e Obstetrícia, Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Botucatu, UNESP, Distrito de Rubião Jr s/n, 18610-000 Botucatu, SP, Brazil. email@example.com
ETHNOPHARMACOLOGICAL RELEVANCE: Bauhinia forficata Link, commonly known as "paw-of-cow", is widely used in Brazilian folk medicine for the treatment of diabetes. AIM OF THIS STUDY: To evaluate the effect of Bauhinia forficata treatment on maternal-fetal outcome and antioxidant systems of streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Virgin female Wistar rats were injected with 40 mg/kg streptozotocin before mating. Oral administration of an aqueous extract of Bauhinia forficata leaves was given to non-diabetic and diabetic pregnant rats at increasing doses: 500 mg/kg from 0 to 4th day of pregnancy, 600 mg/kg from 5th to 14th day and 1000 mg/kg from 15th to 20th day. At day 21 of pregnancy the rats were anaesthetized with ether and a maternal blood sample was collected for the determination superoxide dismutase (SOD) and reduced glutathione (GSH). The gravid uterus was weighed with its contents and fetuses were analyzed. RESULTS AND CONCLUSION: The data showed that the diabetic dams presented an increased glycemic level, resorption, placental weight, placental index, and fetal anomalies, and reduced GSH and SOD determinations, live fetuses, maternal weight gain, gravid uterine weight, and fetal weight. It was also verified that Bauhinia forficata treatment had no hypoglycemic effect, did not improve maternal outcomes in diabetic rats, but it contributed to maintain GSH concentration similarly to non-diabetic groups, suggesting relation with the decreased incidence of visceral anomalies.
PMID: 18155864 [PubMed - indexed for MEDLINE]
Antioxidant activity of leaf extracts from Bauhinia monandra.
Argolo AC, Sant'Ana AE, Pletsch M, Coelho LC.
Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, S/N Cidade Universitária, Pernambuco, Brazil.
Bauhinia monandra Kurz. is used in Brazil for the treatment of diabetes. Since this activity may be correlated with the presence of antioxidant compounds, leaf extracts of B. monandra were evaluated for their radical scavenging capacity (RSC). An ethanolic extract was taken up in aqueous methanol and partitioned with hexane, chloroform, ethyl acetate to yield three organic extracts together with remaining aqueous extract. The RSC was determined spectrophotometrically using 1,1-diphenylpicrylhydrazyl free radical (DPPH). The chloroform and ethyl acetate extracts were the most appropriate as sources of antioxidant compounds as shown by their inhibition concentration (IC50) and inhibition percentage (IP) values. The antioxidant activity of such extracts was attributed to the presence of three compounds of different polarities (flavonoids and steroids). The chloroform and ethyl acetate extracts exhibited an IC50 of approximately 2 mg/g DPPH and IP values in the range of 60-65%. The results indicate that the extracts of B. monandra have a very potent antioxidant activity, compared with the pure catechins used as positive controls and with other plant extracts.
PMID: 15246449 [PubMed - indexed for MEDLINE]
Anti-inflammatory activity of a novel flavonol glycoside from the Bauhinia variegata Linn.
Yadava RN, Reddy VM.
Natural Products Laboratory, Department of Chemistry, Dr. H.S. Gour University, Sagar (M.P.) 470003, India. firstname.lastname@example.orgBauhinia variegata Linn. (Leguminosae) is commonly known as 'Kachnar' in Hindi. It is distributed almost throught India. Its powdered bark is traditionally used for tonic, astrain, ulcers. It is also useful in skin diseases. The roots are used as antidote to snake poison. The present article deals with the isolation and structural elucidation of a novel flavonol glycoside 5,7,3',4'-tetrahydroxy-3-methoxy-7-O-alpha-L-rhamnopyranosyl(1-->3)-O-beta-galactopyranoside (1) from the roots of Bauhinia Variegata and its structure was identified by spectral analysis and chemical degradations. The novel compound (1) showed anti-inflammatory activity.
PMID: 12737399 [PubMed - indexed for MEDLINE]
Antinociceptive, anti-inflammatory and antipyretic properties of the aqueous extract of Bauhinia purpurea leaves in experimental animals.
Zakaria ZA, Wen LY, Abdul Rahman NI, Abdul Ayub AH, Sulaiman MR, Gopalan HK.
Faculty of Pharmacy, Universiti Teknologi Mara, Shah Alam, Selangor, Malaysia. email@example.comOBJECTIVE: The present study was carried out to determine the antinociceptive, anti-inflammatory and antipyretic activities of the aqueous extract of Bauhinia purpurea leaves using animal models. MATERIALS AND METHODS: The air-dried, powdered leaves (approximately 20 g) were soaked in distilled water (1:20; w/v) at room temperature for 72 h and the supernatant obtained was freeze-dried. The crude dried extract (approximately 2.4 g) was prepared in doses of 6.0, 30.0 and 60.0 mg/kg, and subjected to the respective antinociceptive (abdominal constriction, hot plate and formalin tests), anti-inflammatory (carrageenan-induced paw edema test) and antipyretic (brewer's yeast-induced pyrexia test) assays. RESULTS:The results obtained indicate that the extract possessed significant (p < 0.05) antinociceptive, anti-inflammatory and antipyretic activities, which were not dependent on the doses of extract used. The highest concentration of extract was less effective as an anti-inflammatory and an antipyretic agent. CONCLUSION: This study showed that the aqueous extract of B. purpurea leaves possesses potential pharmacological activities that require further investigation and, thus, confirms the folklore use of the plant in the treatment of ailments associated with pain and inflammation. Copyright 2007 S. Karger AG, Basel.
PMID: 17917444 [PubMed - indexed for MEDLINE]
Antiinflammatory activities of flavonoids and a triterpene caffeate isolated from Bauhinia variegata.
Rao YK, Fang SH, Tzeng YM.
Institute of Biotechnology, Chaoyang University of Technology, Wufeng, Taiwan, ROC.
In the continuing search for novel antiinflammatory agents, six flavonoids, namely kaempferol (1), ombuin (2), kaempferol 7,4'-dimethyl ether 3-O-beta-D-glucopyranoside (3), kaempferol 3-O-beta-D-glucopyranoside (4), isorhamnetin 3-O-beta-D-glucopyranoside (5) and hesperidin (6), together with one triterpene caffeate, 3beta-trans-(3,4-dihydroxycinnamoyloxy)olean-12-en-28-oic acid (7) were isolated from the non-woody aerial parts of Bauhinia variegata. Compounds 1-7 were evaluated as inhibitors of some macrophage functions involved in the inflammatory process. These seven compounds significantly and dose dependently inhibited lipopolysaccharide (LPS) and interferon (IFN)-gamma induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12]. The concentration causing a 50% inhibition (IC50) of NO, TNF-alpha and IL-12 production by compounds 1, 2 and 7 was approximately 30, 50 and 10 microM, respectively, while at 50, 200 and 40 microM compounds 3, 4, and 5, 6 showed 15-30% inhibition, respectively. On the other hand, compounds 3 and 7 showed no inhibitory effect, while compounds 1, 4-6 reduced by around 10-30% the synthesis of NO by macrophages, when inducible NO synthase was already expressed with LPS/IFN-gamma for 24 h. These experimental findings lend pharmacological support to the suggested folkloric uses of the plant B. variegata in the management of inflammatory conditions.
PMID: 18384188 [PubMed - indexed for MEDLINE]
Hypoglycemic activity of two Brazilian Bauhinia species: Bauhinia forficata L. and Bauhinia monandra Kurz.
Atividade hipoglicemiante de duas espécies de Bauhinia brasileira: Bauhinia forficata L. and Bauhinia monandra Kurz.
Fábio de Sousa MenezesI, II, *; Andréa Barreto Mattos MintoI; Halliny Siqueira RuelaIII; Ricardo Machado KusterIII; Helen SheridanII; Neil FrankishII
IDepartamento de Produtos Naturais e Alimentos, Faculdade de Farmácia, Centro de Ciências da Saúde, Cidade Universitária, 21941-590, Rio de Janeiro, RJ, Brazil
IISchool of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Universtity of Dublin, 23 Westland Row, Dublin 2, Ireland
IIINúcleo de Pesquisas de Produtos Naturais, Centro de Ciências da Saúde, Bloco H, Cidade Universitária, 21941-590, Rio de Janeiro, RJ, Brazil
The hypoglycemic activity of aqueous extracts from Bauhinia forficata L. and Bauhinia monandra Kurz leaves (10% w/v) was evaluated in normoglycemic mice. Both extracts have shown hypoglycemic activity using this methodology. It was also possible to isolate two flavonoids from B. forficata L., 3,7-di-O-a-rhamnopyranosylquercetin and 3,7-di-O-a-rhamnopyranosylkaempferol (kaempferitrin), whose structures were elucidated by usual NMR techniques. Only the quercetin derivative was identified in B. monandra aqueous extract by HPLC.
Keywords: Bauhinia forficata, Bauhinia monandra, Leguminosae, hypoglycemic activity, flavonoids, HPLC.
Extratos aquosos das folhas de Bauhinia forficata L. e Bauhinia monandra Kurz (10% p/v) foram testados em camundongos normoglicêmicos, objetivando averiguar a sua atividade hipoglicemiante. Ambos os extratos mostraram atividade hipoglicemiante na metodologia empregada. Ainda, foi possível isolar de B. forficata L. dois flavonóides, quercetina-3,7-O-dirhamnosido e kaempferol-3,7-O-dirhamnosido, sendo as estruturas estabelecidas por técnicas clássicas de RMN. Apenas o derivado da quercetina foi identificado no extrato aquoso de Bauhinia monandra por CLAE.
Unitermos: Bauhinia forficata, Bauhinia monandra, Leguminosae, atividade hipoglicemiante, flavonoides, CLAE.
Organic Hope, in accordance with the Rio de
Janeiro Biodiversity Protocol uses only cultivated Bauhinia plants to
manufacture Bauhika 10:1 standardized extract. The ancient Mayans used Bauhinia
as part of their daily diet in the form of tea as a blood purifier. They
attributed healing properties to the drink and up until today the drink is still
popular in Honduran tradition. Brazilians have used Bauhinia extract for over 50
years as part of an overall health program to maintain their immune system at
L.G. from New Mexico had
this to say
: I am pretty sure Bauhika is working! My blood sugar is
now normal without being hypoglycemic. I am now comfortably going out and I don't
feel as conscious about my blood sugar as I used to be. Hey, I think this
product is wonderful and I recommend it to anyone who has diabetes!
Other recommendations for successfully managing diabetes are Proper Nutrition
to address hyperlipidemia Atherosclerosis and hypertension, if present.
- Regular physical activity can improve insulin
- Promote weight loss and maintenance of ideal
- Improve cardiovascular health
- Reduce the need for medications and insulin
and enhance productivity, quality of life, and sense of well-being