Wobenzym N Systemic Enzymes
The Miracle of Oral Enzymes - Fighting Inflammation Naturally
Everything you ever wanted to know about enzymes, what they are, how they work, clinical studies, research, and how they can benefit your health beyond your wildest expectations
Wobenzym N is an enzyme preparation originally designed in Germany in the 1960s and is a natural anti-inflammatory with many additional health benefits.
Although its original use was primarily to treat osteoarthritis, studies have revealed that Wobenzym N lowers C-reactive protein levels (a marker of chronic infection in the body) on average by 30%!
The latest research, published in the New England Journal of Medicine, has documented that individuals with high levels of C-reactive protein have up to 6 times the likelihood of a heart attack or strokes as individuals with lower levels.
Wobenzym N acts as a natural, safe alternative to anti-inflammatory drugs such as Ibuprofen.
Furthermore, some Olympic teams have used Wobenzym to reduce injuries by as much as 50% and to enhance healing after injury. This is partly due to the bioflavonoids ability to prevent the discoloration and local pain associated with traumatic injuries. For these same reasons, leading surgeons now routinely prescribe Wobenzym to prevent bruising and edema and the associated pain for their post-surgical patients.
As more and more uses of Wobenzym are discovered, the list of health problems benefiting from Wobenzym continues to grow and include:
What are Enzymes, and how are they organized?
Enzymes are delicate proteins, catalysts responsible not only for breaking down food, but for a host of other day-to-day processes, including transforming minerals into alkaline detoxifiers that neutralize the acid of our highly acidic diet. Enzymes are critically necessary for achieving our balanced pH, as well as our balanced diet.
Enzymes allow certain metabolic processes to take place that otherwise would not occur without their presence. Enzymes assist in converting one substance (called a substrate) into another substance. During this process, the enzyme itself is not consumed and is available to perform its function over and over.
The German physician William Friedrich was the first to use the term "enzyme". Since 1897, the term is generally used within the scientific realm to refer to all biocatalysts.
Structurally, all enzymes consist of chains of amino acids. There are 20 amino acids from which all protein are composed. It is the specific sequence and tridimensional nature of amino acids that determine the spatial structure and function of an enzyme.
Many enzymes also contain components that are not amino acids, but are critical to their proper function. These components are referred to as co-factors. An example of a co-factor could be a specific vitamin or mineral that helps the enzyme catalyze a particular reaction.
Enzymes may only exert their effect in a certain range of pH values and temperatures. They are very sensitive, and are typically destroyed to a large extent by the gastric acid within our stomachs. Active enzymes play a crucial role in supporting all immune system functions.
How do Enzymes Work?
Science has been able to identify approximately 3,000 enzymes in the body, each with a very specific role. Most enzymes are used for the body's normal metabolic processes (digestion, breathing). Certain enzymes control the production of important hormones in the body. Enzymes also destroy environmental toxins and free radicals that are formed both from endogenous and exogenous sources.
Enzyme reaction: the lock-and-key principle
Enzymes have an active center. Under a powerful microscope, this is the area that often looks like a concavity or a depression. Certain materials fit into this depression causing the enzyme to convert and change. In the case of proteolytic enzymes (which break down protein), protein molecules attach to the active center of the enzyme, and then the amino acids divide in specific locations. Each enzyme is substrate specific and catalyzes a small number of reactions. These reactions often take place in series often referred to as a cascade. Enzyme cascades allow multiple controls over a large number of processes.
Through a chemical reaction, enzymes ensure that a specific balance ultimately results between the substrate and the final product.
"Systemic enzyme support" consists of ingesting combinations of different enzymes, which modulate the natural reactions in the body. Specifically, these enzymes can help support healthy blood flow and the immune system*. Enzymes are like the police officers of our bodies that regulate its biochemical reactions.
Enzyme Effectiveness - What does "systemic enzyme support" mean?
The word systemic¯ means body wide. Systemic enzymes are those that operate not just for digestion but throughout your body in every system and organ.
In order to ensure that the systemic effect of the enzyme therapy unfolds, active enzyme molecules must be available in the small intestine for absorption. In order to penetrate through the acidic environment of the stomach, enzyme tablets must be enteric-coated in order to reach their appropriate target.
Specific enzymes used in a systemic enzyme formulation have effects on different functions in the body. In order to have a maximal effect, a combination of plant-based enzymes (bromelain and papain), with animal-based enzymes including trypsin and chymotrypsin is necessary.
These body wide proteolytic (protein eating) enzymes have the following actions:
They are the first line of defense against inflammation. Inflammation is a reaction by the immune system to an irritation. Let's say you have an injured right knee. The immune system sensing the irritation the knee is undergoing creates a protein chain called a Circulating Immune Complex (CIC for short), tagged specifically for that right knee. (The Nobel Prize in biology was won in 1999 by a scientist who discovered this tagging mechanism). This CIC floats down to the right knee and causes pain, redness and swelling are the classic earmarks for inflammation. This at first is a beneficial reaction; it warns us that a part of ourselves is hurt and needs attention. But, inflammation is self-perpetuating, itself creating an irritation that the body makes CIC's to in response!
Aspirin, Ibuprofen, Celebrex, Vioxx and the rest of the Non Steroidal Anti Inflammatory Drugs all work by keeping the body from making all CIC's. This ignores the fact that some CIC's are vital to life, like those that maintain the lining of the intestine and those that keep the kidneys functioning! Not to mention the fact that the NSAID's, along with acetaminophen, are highly toxic to the liver. Every year 20,000 Americans die from these over the counter drugs and another 100,000 will wind up in the hospital with liver damage, kidney damage or bleeding intestines from the side effects of these drugs.
Systemic enzymes on the other hand are perfectly safe and free of dangerous side effects. They have no LD-50, or toxic dose. Best of all systemic enzymes can tell the difference between the good CIC's and the bad ones because hydrolytic enzymes are lock and key mechanisms and their "teeth" will only fit over the bad CIC's. So instead of preventing the creation of all CIC's, systemic enzymes just create the bad ones and in so doing lower inflammation everywhere. With that, pain is lowered also.
Enzymes eat scar tissue and fibrosis. Fibrosis is scar tissue and most doctors learn in anatomy that it is fibrosis that eventually kills us all. Let me explain. As we age, which starts at 27, we have a diminishing of the bodies output of enzymes. This is because we make a finite amount of enzymes in a lifetime and we use up a good deal of them by the time we are 27. At that point the body knows that if it keeps up that rate of consumption we'll run out of enzymes and be dead by the time we reach our 40's. (Cystic Fibrosis patients who have virtually no enzyme production to speak of, even as children usually don't make it past their 20's before they die of the restriction and shrinkage in the lungs from the formation of fibrosis or scar tissue).
So our body in it's wisdom begins to dole out our enzymes with an eyedropper instead of with a tablespoon; as a result the repair mechanism of the body goes out of balance and has nothing to reduce the over abundance of fibrin it deposits in nearly every thing from simple cuts, to the inside of our internal organs and blood vessels. This is when most women begin to develop things like fibrocystic breast disease, uterine fibroids, endometriosis, and we all grow arterial sclerotic (meaning scar tissue) plaque, and have fibrin beginning to spider web its way inside of our internal organs reducing their size and function over time. This is why as we age our wounds heal with thicker, less pliable, weaker and very visible scars.
If we replace the lost enzymes we can control and reduce the amount of scar tissue and fibrosis our bodies have. As physicians in the US are now discovering, even old scar tissue can be eaten away¯ from surgical wounds, pulmonary fibrosis, kidney fibrosis and even keloids years after their formation. Medical doctors in Europe and Asia have known this and have used orally administered enzymes for these situations for over 40 years!
The blood is not only the river of life, it is also the river through which the cells and organs dispose of their garbage and dead material. Enzymes improve circulation by eating the excess fibrin that causes blood to sometimes get as thick as catsup or yogurt, creating the perfect environment for the formation of clots. All of this material is supposed to be cleared by the liver on its "first pass", or the first time it goes through but given the sluggish and near toxic or toxic states of everyone's liver these days that seldom happens. So the sludge remains in the blood waiting for the liver to have enough free working space and enough enzymes to clean the trash out of the blood. This can take days, and in some cases, weeks!
When systemic enzymes are taken, they stand ready in the blood and take the strain off of the liver by:
Cleaning excess fibrin from the blood and reducing the stickiness of blood cells. These two actions minimize the leading causes of stroke and heart attack causing blood clots.
Breaking dead material down small enough that it can immediately pass into the bowel.
Cleanse the FC receptors on the white blood cells improving their function and availability to fight off infection.
And here we come to the only warning we have to give concerning the use of systemic enzymes - don't use the product if you are a hemophiliac or are on prescription blood thinners like Coumadin, Heparin and Plavix, without direct medical supervision. The enzymes cause the drugs to work better so there is the possibility of thinning the blood too much.
Immune System Modulating
Enzymes are adaptogenic seeking to restore a steady state to the body. When the immune system is running low we become susceptible to infectious disease, when it's cranked up too high then the system creates antibodies that attack it's own tissues as are seen in the auto immune diseases of MS, Rheumatoid Arthritis, and Lupus. Here the enzymes will tone down immune function and eat away at the antibodies the immune system is making to attack its bodies own tissue.
Viruses harm us by replicating in our bodies. To do this a virus must bond itself to the DNA in our cells through the medium of its exterior protein cell wall. Anything that disrupts that cell wall inhibits the ability of viral replication by rendering individual viruses inert. Systemic enzymes can tell the difference between the proteins that are supposed to be in your body and those that are foreign or not supposed to be there, (again the enzyme lock and key mechanism).
One note: many in the States have learned in school that enzymes are too big a protein to be absorbed through the gut. The pioneering research done in the US by Dr. Max Wolf (MD & PhD x7) at Columbia University in the 40's through the 70's has not made it to the awareness of most doctors. There are currently over 200 peer reviewed research articles dealing with the absorption, utilization and therapeutic action of orally administered systemic enzymes. A search through Pub Med using the key words: serrapeptase, papain, bromelain, trypsin, chymo trypsin, nattokinase and systemic enzyme will yield some of the extensive work. Systemic enzymes now have a 4 decade plus history of widespread medical use in central Europe and Japan.
Where is systemic enzyme support used?
There are many areas of application for systemic enzyme support. Enzymes support the body in a number of areas, including healthy blood flow, immune support, joint health as well as others.
In order for the enzymes not to be destroyed, the tablet must be coated to allow the enzymes to reach the small intestine where they can be absorbed.
It is also very important to take enzyme tablets on an empty stomach, at least 30 minutes to 1 hour before meals. The enzymes have a better chance of absorption through the intestinal walls and ultimately into the blood.
Who should take enzymes only under medical supervision?