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The Miracle of Oral Enzymes

Everything you ever wanted to know about enzymes, what they are,
how they work, clinical studies, research, and how they can benefit
your health
beyond your wildest expectations

Wobenzym is an enzyme preparation originally designed in Germany
in the 1960s and is a natural anti-inflammatory with many additional
health benefits
Wobenzym N Authorized Merchant

Although its original use was primarily to treat osteoarthritis, studies have revealed that Wobenzym lowers C-reactive protein levels (a marker of chronic infection in the body) on average by 30%!

The latest research, published in the New England Journal of Medicine, has documented that individuals with high levels of C-reactive protein have up to 6 times the likelihood of a heart attack or strokes as individuals with lower levels.

Wobenzym acts as a natural, safe alternative to anti-inflammatory drugs such as Ibuprofen.

Furthermore, some Olympic teams have used Wobenzym to reduce injuries by as much as 50% and to enhance healing after injury. This is partly due to the bioflavonoids ability to prevent the discoloration and local pain associated with traumatic injuries. For these same reasons, leading surgeons now routinely prescribe Wobenzym to prevent bruising and edema and the associated pain for their post-surgical patients.

As more and more uses of Wobenzym are discovered, the list of health problems benefiting from Wobenzym continues to grow and include:






Reducing the incidence of blood clots, known to be induced by the sudden breakdown of vulnerable plaque
Improving feelings of well-being due to its antioxidant effects
Reducing the incidence of heart attacks and strokes because of its anti-thrombotic, anti-spasmodic, anti-arrhythmic and cholesterol lowering abilities
Helping to resolve many of the molecular features of aging
Providing protection from environmental toxins in the air, water and food
Treating autoimmune and rheumatic illnesses, such as osteo and rheumatoid arthritis, joint and muscle pain
Lowering inflammation involved in allergies and alleviates the symptoms for the sufferer

    1. Systemic Enzyme Therapy-Supplement to The Art of Getting Well- A Must read article about the healing properties of enzymes

What are Enzymes, and how are they organized?

Enzymes are delicate proteins, catalysts responsible not only for breaking down food, but for a host of other day-to-day processes, including transforming minerals into alkaline detoxifiers that neutralize the acid of our highly acidic diet. Enzymes are critically necessary for achieving our balanced pH, as well as our balanced diet.
Enzymes allow certain metabolic processes to take place that otherwise would not occur without their presence. Enzymes assist in converting one substance (called a substrate) into another substance. During this process, the enzyme itself is not consumed and is available to perform its function over and over.

The German physician William Friedrich was the first to use the term "enzyme". Since 1897, the term is generally used within the scientific realm to refer to all biocatalysts.

Structurally, all enzymes consist of chains of amino acids. There are 20 amino acids from which all protein are composed. It is the specific sequence and tridimensional nature of amino acids that determine the spatial structure and function of an enzyme.

Many enzymes also contain components that are not amino acids, but are critical to their proper function. These components are referred to as co-factors. An example of a co-factor could be a specific vitamin or mineral that helps the enzyme catalyze a particular reaction.
Enzymes may only exert their effect in a certain range of pH values and temperatures. They are very sensitive, and are typically destroyed to a large extent by the gastric acid within our stomachs. Active enzymes play a crucial role in supporting all immune system functions.
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How do Enzymes Work?

Science has been able to identify approximately 3,000 enzymes in the body, each with a very specific role. Most enzymes are used for the body's normal metabolic processes (digestion, breathing). Certain enzymes control the production of important hormones in the body. Enzymes also destroy environmental toxins and free radicals that are formed both from endogenous and exogenous sources.

Enzyme reaction: the lock-and-key principle

Enzymes have an active center. Under a powerful microscope, this is the area that often looks like a concavity or a depression. Certain materials fit into this depression causing the enzyme to convert and change. In the case of proteolytic enzymes (which break down protein), protein molecules attach to the active center of the enzyme, and then the amino acids divide in specific locations. Each enzyme is substrate specific and catalyzes a small number of reactions. These reactions often take place in series often referred to as a cascade. Enzyme cascades allow multiple controls over a large number of processes.

Through a chemical reaction, enzymes ensure that a specific balance ultimately results between the substrate and the final product.

"Systemic enzyme support" consists of ingesting combinations of different enzymes, which modulate the natural reactions in the body. Specifically, these enzymes can help support healthy blood flow and the immune system*. Enzymes are like the police officers of our bodies that regulate its biochemical reactions.
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Enzyme Effectiveness - What does "systemic enzyme support" mean?

The word “systemic” means body wide. Systemic enzymes are those that operate not just for digestion but throughout your body in every system and organ.
In order to ensure that the systemic effect of the enzyme therapy unfolds, active enzyme molecules must be available in the small intestine for absorption. In order to penetrate through the acidic environment of the stomach, enzyme tablets must be enteric-coated in order to reach their appropriate target.

Specific enzymes used in a systemic enzyme formulation have effects on different functions in the body. In order to have a maximal effect, a combination of plant-based enzymes (bromelain and papain), with animal-based enzymes including trypsin and chymotrypsin is necessary.
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Natural Anti-Inflammatory
They are the first line of defense against inflammation. (1,2,3). Inflammation is a reaction by the immune system to an irritation. Let’s say you have an injured right knee. The immune system sensing the irritation the knee is undergoing creates a protein chain called a Circulating Immune Complex (CIC for short), tagged specifically for that right knee. (The Nobel Prize in biology was won in 1999 by a scientist who discovered this tagging mechanism). This CIC floats down to the right knee and causes pain, redness and swelling are the classic earmarks for inflammation. This at first is a beneficial reaction; it warns us that a part of ourselves is hurt and needs attention. But, inflammation is self-perpetuating, itself creating an irritation that the body makes CIC’s to in response!

Aspirin, Ibuprofen, Celebrex, Vioxx and the rest of the Non Steroidal Anti Inflammatory Drugs all work by keeping the body from making all CIC's. This ignores the fact that some CIC’s are vital to life, like those that maintain the lining of the intestine and those that keep the kidneys functioning! Not to mention the fact that the NSAID’s, along with acetaminophen, are highly toxic to the liver. Every year 20,000 Americans die from these over the counter drugs and another 100,000 will wind up in the hospital with liver damage, kidney damage or bleeding intestines from the side effects of these drugs. (4,5).

Systemic enzymes on the other hand are perfectly safe and free of dangerous side effects. They have no LD-50, or toxic dose. (6). Best of all systemic enzymes can tell the difference between the good CIC’s and the bad ones because hydrolytic enzymes are lock and key mechanisms and their "teeth" will only fit over the bad CIC’s. So instead of preventing the creation of all CIC’s, systemic enzymes just “eat” the bad ones and in so doing lower inflammation everywhere. With that, pain is lowered also.

Anti Fibrosis

Enzymes eat scar tissue and fibrosis. (7). Fibrosis is scar tissue and most doctors learn in anatomy that it is fibrosis that eventually kills us all. Let me explain. As we age, which starts at 27, we have a diminishing of the bodies’ output of enzymes. This is because we make a finite amount of enzymes in a lifetime and we use up a good deal of them by the time we are 27. At that point the body knows that if it keeps up that rate of consumption we’ll run out of enzymes and be dead by the time we reach our 40’s. (Cystic Fibrosis patients who have virtually no enzyme production to speak of, even as children usually don’t make it past their 20’s before they die of the restriction and shrinkage in the lungs from the formation of fibrosis or scar tissue).

So our body in it's wisdom begins to dole out our enzymes with an eyedropper instead of with a tablespoon; as a result the repair mechanism of the body goes out of balance and has nothing to reduce the over abundance of fibrin it deposits in nearly every thing from simple cuts, to the inside of our internal organs and blood vessels. This is when most women begin to develop things like fibrocystic breast disease, uterine fibroids, endometriosis, and we all grow arterial sclerotic (meaning scar tissue) plaque, and have fibrin beginning to spider web its way inside of our internal organs reducing their size and function over time. This is why as we age our wounds heal with thicker, less pliable, weaker and very visible scars.

If we replace the lost enzymes we can control and reduce the amount of scar tissue and fibrosis our bodies have. As physicians in the US are now discovering, even old scar tissue can be “eaten away” from surgical wounds, pulmonary fibrosis, kidney fibrosis and even keloids years after their formation. Medical doctors in Europe and Asia have known this and have used orally administered enzymes for these situations for over 40 years!

Blood Cleansing

The blood is not only the river of life, it is also the river through which the cells and organs dispose of their garbage and dead material. Enzymes improve circulation by eating the excess fibrin that causes blood to sometimes get as thick as catsup or yogurt, creating the perfect environment for the formation of clots. All of this material is supposed to be cleared by the liver on its "first pass", or the first time it goes through but given the sluggish and near toxic or toxic states of everyone's liver these days that seldom happens. So the sludge remains in the blood waiting for the liver to have enough free working space and enough enzymes to clean the trash out of the blood. This can take days, and in some cases, weeks! (8).

When systemic enzymes are taken, they stand ready in the blood and take the strain off of the liver by:

  1. Cleaning excess fibrin from the blood and reducing the stickiness of blood cells. These two actions minimize the leading causes of stroke and heart attack causing blood clots. (8).
  2. Breaking dead material down small enough that it can immediately pass into the bowel. (8).
  3. Cleanse the FC receptors on the white blood cells improving their function and availability to fight off infection. (9).

And here we come to the only warning we have to give concerning the use of systemic enzymes - don't use the product if you are a hemophiliac or are on prescription blood thinners like Coumadin, Heparin and Plavix, without direct medical supervision. The enzymes cause the drugs to work better so there is the possibility of thinning the blood too much.

Immune System Modulating

Enzymes are adaptogenic seeking to restore a steady state to the body. (9). When the immune system is running low we become susceptible to infectious disease, when it’s cranked up too high then the system creates antibodies that attack it's own tissues as are seen in the auto immune diseases of MS, Rheumatoid Arthritis, and Lupus. Here the enzymes will tone down immune function and eat away at the antibodies the immune system is making to attack its bodies own tissue.

Virus Fighting

Viruses harm us by replicating in our bodies. To do this a virus must bond itself to the DNA in our cells through the medium of its exterior protein cell wall. Anything that disrupts that cell wall inhibits the ability of viral replication by rendering individual viruses inert. (10,11). Systemic enzymes can tell the difference between the proteins that are supposed to be in your body and those that are foreign or not supposed to be there, (again the enzyme lock and key mechanism).

One note: many in the States have learned in school that enzymes are too big a protein to be absorbed through the gut. The pioneering research done in the US by Dr. Max Wolf (MD & PhD x7) at Columbia University in the 40’s through the 70’s has not made it to the awareness of most doctors. There are currently over 200 peer reviewed research articles dealing with the absorption, utilization and therapeutic action of orally administered systemic enzymes. A search through Pub Med using the key words: serrapeptase, papain, bromelain, trypsin, chymo trypsin, nattokinase and systemic enzyme will yield some of the extensive work. Systemic enzymes now have a 4 decade plus history of widespread medical use in central Europe and Japan.
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Where is systemic enzyme support used?
There are many areas of application for systemic enzyme support. Enzymes support the body in a number of areas, including healthy blood flow, immune support, joint health as well as others.*
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Enzymes in tablet form
In order for the enzymes not to be destroyed, the tablet must be coated to allow the enzymes to reach the small intestine where they can be absorbed.

It is also very important to take enzyme tablets on an empty stomach, at least 30 minutes to 1 hour before meals. The enzymes have a better chance of absorption through the intestinal walls and ultimately into the blood.
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Who should take enzymes only under medical supervision?
  • Pregnant women or nursing mothers
  • Patients with bleeding disorders or taking medication altering the ability of the blood to clot (such as warfarin)
  • Patients with liver or kidney problems

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  1. Systemic Enzyme Therapy-Supplement to The Art of Getting Well- A Must read article about the healing properties of enzymes

1. What is Wobenzym®N?

Wobenzym®N is a clinically supported combination of specific enteric-coated enzymes and the leading natural solution in systemic enzymes.

Dr. Max Wolf designed Wobenzym®N using a sophisticated combination of the plant based enzymes bromelain (pineapple extract) and papain (papaya extract), natural pancreatic enzymes trypsin and chymotrypsin, and the antioxidant flavonoid rutin.

Each Wobenzym®N tablet is protected by an enteric-coated shell. This ensures that enzymes can bypass the acidic environment of the stomach and reach the small intestine where they can be absorbed and utilized.

Wobenzym®N's precise enzyme formulation assists the body's maintenance and support of a healthy immune system.* Back To Top

2. What is systemic enzyme support?

"Systemic enzyme support" describes an approach whereby enzymes are utilized to assist the body's various regulatory and communication systems, specifically the immune system. A balanced immune system is a prerequisite for the condition we all want: good health. In order to make sure that the systemic effect of the enzyme support succeeds, active enzyme molecules must be available in the small intestine for absorption.
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3. Why should I take Wobenzym®N?

Taking Wobenzym®N as directed will assist your body's natural function in the:

  • Promotion of healthy joints and muscles*
  • Stimulation of healthy circulation*
  • Strengthening of the immune system*
  • Improvement of health and aging process*

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4. Is Wobenzym®N safe to use?

Wobenzym®N is extremely safe and has been used by over 100 million people for over 40 years all around the world without a single instance or documented case of significant harm. Over 70 million dollars have been spent on decades of clinical studies assessing the benefits of Wobenzym®N with results indicating the product to be very safe.
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5. Are there any special precautions?

  • Wobenzym®N should not be taken by individuals who are pregnant or breast feeding
  • Wobenzym®N should not be taken by individuals suffering from bleeding disorders or liver damage
  • Wobenzym®N should not be taken by individuals who are on anticoagulant drugs (such as Warfarin)
  • Wobenzym®N should not be taken in combination with Aspirin
  • Wobenzym®N can be taken with antibiotics

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6. Does Wobenzym®N have any side effects?

Some people have experienced small digestive disruptions such as diarrhea and excess gas. This can be minimized by taking smaller serving sizes more frequently throughout the day. If these symptoms persist, consult with your healthcare practitioner.
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7. Are there ingredients in Wobenzym®N that may affect my food allergies?

All of the ingredients used in the formulation of Wobenzym®N are listed on the bottle label. If you have an allergy to any of the ingredients listed on the label, specifically pineapple, papaya, rutin, trypsin or chemotrypsin, please contact you healthcare practitioner for further direction. Wobenzym®N is manufactured under the strictest cGMP conditions and is free of contaminants.
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8. What are the potential uses of Wobenzym®N?

Potential Uses

Wobenzym® N Benefit

Joint Health Wobenzym®N supports joint health and mobility.*
Healthy Circulation Support Wobenzym®N promotes healthy blood flow.*
Immune System Support Wobenzym®N is used by many people in the maintenance and support of a balanced immune system.*
Sports Injury Recovery Wobenzym®N has been used for many years in the relief of muscle pain following exercise and other repetitive motion.*
Healthy Aging As we age, the body's homeostasis begins to shift. Wobenzym®N assists in healthy immune function at any age.*

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9. How should I take Wobenzym®N?

Direction of Use
When should I take Wobenzym®N?
We recommend that you take Wobenzym®N on an empty stomach at least 30 minutes prior to your next meal or at least 2 hours after your last meal.
How should I take Wobenzym®N?
The Wobenzym®N tablets need to be swallowed with a glass of water making sure not to chew the tablets. This will prevent damage to the enteric coated protective layer of the tablet. This coating allows the tablets to arrive at the small intestine where they can be effectively absorbed.
Can I take Wobenzym®N with any liquid?
No, in order for Wobenzym®N to function properly it should be taken with a glass of water at room temperature or below. If Wobenzym®N is taken with a warm to hot liquid such as coffee or tea the enteric coating on the tablets may be compromised. Taking the tablets with milk may disturb the absorption of enzymes within the small intestine.
What is the appropriate serving size of Wobenzym®N?
The recommended serving size for the maintenance of good immune and circulatory function is three (3) tablets. However, this can be increased as recommended by your healthcare practitioner.
How many servings should I take per day?
The recommended number of servings per day for the maintenance of good immune and circulatory function is twice (2) per day. However, this can be increased as recommended by your healthcare practitioner.
Can I accidentally take too many?
The 160 clinical studies assessing the benefits of Wobenzym®N suggest that if the amount of enzymes ingested exceeds the body's need it is simply excreted through regular bowel movement. Over 100 million people have taken Wobenzym®N with no indication of toxicity.
When should I stop taking Wobenzym®N?
Wobenzym®N should be taken as recommended by your healthcare practitioner. It should be noted that Wobenzym®N can and has been used by people for over 60 years for continual immune support.
Why do I have to take so many tablets?
Enzymes are rather large protein molecules. As such only small percentages are absorbed and pass through the intestinal wall and reach the bloodstream. Therefore, the quantity of tablets consumed is crucial to ensure adequate absorption.
The story of enzymes is as fascinating in its details as it is amazing in its applications in promoting human health and wellbeing. Enzymes are proteins that are an integral part of Nature. In fact, life without enzymes would not be possible. Enzymes are needed for each and every chemical reaction that make life possible. No vitamin, mineral or hormone can exert its beneficial effects in the human body without the involvement of enzymes. Despite their central role in all bodily functions, it is only now that the full import of enzymes in human health and disease has begun to be fully appreciated.
MUCOS Pharma, the pioneer in systemic enzyme therapy, has been the standard bearer for the last fifty years in having paved the way to elucidate the function of enzymes, and their use as an oral systemic therapy.
The history of enzyme research reads quite like a detective story, as diligence of dedicated scientists tested the secrets of enzyme function and developed preparations to alleviate human pain and suffering. It all started with a simple question: What are the enzymes? Years, even decades, of work finally yielded insights into the architecture of enzymes, which is beguiling in its simplicity and elegance, yet embodies the intricacies of their function.
What Are Enzymes?
Enzymes are proteins composed of amino acids, the basic building blocks of life, arranged in chains that spontaneously fold into three-dimensional structures. These three-dimensional structures confer specificity of function. Whereas all enzymes are proteins, not all proteins are enzymes. Enzymes are involved in nearly all metabolic and physiological processes in the body. Thus, they are a key in the maintenance of a strong immune system, a robust cardiovascular tree, a healthy and intact central nervous system, and optimal hormonal balance in the body.
The body produces its own supply of enzymes in requisite amounts, as and when they are needed. The enzymes, however, do get "used up" at rates faster than the body can replenish its supplies under a variety of conditions, such as consumption of "junk" foods or intake of medicines. In fact, with advancing years, the body loses its ability to produce sufficient amounts of enzymes to keep up the demands of the body imposed by metabolic attrition. This insufficiency is the root cause of susceptibility to chronic and age-related diseases.
Given that enzymes are required in all cells of the body to assist in chemical reactions, they participate in a myriad of reactions that allow organs, tissues and glands to function optimally and thrive. If the body is imagined as an efficient chemical factory, it is the enzymes that fuel each and every reaction in that factory. As such, enzymes function as catalysts. That is, they make things work at a faster rate. The reason enzymes are needed for bodily functions is that, in their absence, most of the physiological processes would either not take place, or would proceed at an excruciatingly slow speed. In other words, at normal body temperatures, it will be virtually impossible for the cells to perform their tasks speedily and efficiently. That means that enzymes initiate, maintain, accelerate, and terminate biochemical processes in the body to foster health and vitality.
Functions of Enzymes
Since they have unique structure, each enzyme is meant to carry out a specific task. Any given enzyme is evolved to fulfill a definite function, and this specificity allows the body to strictly control the use of enzymes. Once activated, an enzyme will perform its specific function until it is "exhausted," or it is inhibited by another enzyme, in which case its activity is curtailed and/or stopped. As researchers have found out after years of painstaking and laborious work, there is a good reason for this control: It prevents bodily processes from spinning out of control, which may be deleterious to health and wellbeing.
Even casually, the specificity of enzymes suggests that there will be particular types. In fact, Nature has "engineered" families of enzymes for specific tasks. One of the most beneficial and abundant classes of enzymes is referred to as proteolytic enzymes. Enzymes in this category have the ability to "nibble" at other proteins, and break them down into smaller chains of amino acids. Hence the name, proteolytic enzymes, which literally means "chewing up proteins."
On the surface, it might appear counterintuitive to degrade proteins in the body. Are proteins not required for optimal cellular function, and do they not afford good health and vibrancy well into the golden years? Indeed, they do! In disease, however, the human body produces proteins that could potentially have injurious effects, and further compromise health if left unattended. It was precisely this goal that Drs. Max Wolf and Helen Benitez set themselves roughly one-half a century ago when they started their quest to find a wholesome, effective and safe alternative for human health and wellbeing. Of course, their objective was to understand how c comes about and whether natural alternatives could be designed that will not wreak havoc on the human body as radiation and chemotherapy do. Despite their scientific astuteness, little did Drs. Wolf and Benitez anticipate that their systemic enzymes will afford man immense health benefits, irrespective of whether or not systemic enzymes "cured" c.
Drs. Wolf and Benitez, along with Dr. Karl Ransberger, a young biomedical researcher from Germany, tested a large number of enzymes from animal and plant sources. The work was slow, and it progressed in fits and starts, since the researchers had to optimize the conditions to isolate and purify the enzymes. Not only that, they had to struggle to maintain the activity of the enzymes, because the enzymes are notorious for being finicky and unstable. That is, if the enzymes are not handled properly under precisely defined condition, they become inactive. After all, the researchers were working in the 1950s, a time when the basic enzyme technology was still in its infancy, and individual scientists had to rely more on their wits than technology to tweak answers from Nature.
Once Drs. Wolf and Benitez had optimized the conditions necessary to maintain the enzyme activity, they started the next part of their work to combine and evaluate various enzyme formulations in assessing their beneficial effects. These must have been trying times for Drs. Wolf and Benitez. By its very nature, the work was slow, and required almost superhuman patience. After years of dedicated work, they finally experienced the Eureka effect! Their systemic enzymes worked! Perhaps, better than they thought, since beneficial effects of their enzymes were far more varied than they had expected in their wildest expectations.
Benefits of Wobenzym
Why did Wobenzym work so well? To a large extent, the answer rests with the type of enzymes contained in Wobenezym. These are proteolytic enzymes, which cleave other proteins. While under normal physiological condition, proteolytic enzymes maintain homeostasis in the healthy body, they also break down aberrant proteins that may arise during various diseases. Thus, in basic research and several tens of clinical studies carried out over the years under the auspices of MUCOS Pharma, Wobenzym has been found to degrade, for example, harmful and abnormal immune complexes that precipitate autoimmune diseases. Furthermore, immune complexes also thicken the blood, which potentially could trigger an array of diseases. These studies are a matter of public domain, and may be readily retrieved.
In fact, after some 50 years of Dr. Wolf's work, we have come full circle. Dr. Wolf started his research to find a cure for c. After decades of diligent work, almost remarkable determination and scientific insights, proteolytic enzymes have been shown to help c patients. Thus, Wobe-Mugos, a sister product to MUCOS' flagship product Wobenzym, is under consideration by the United States FDA for Orphan Drug status as adjuvant therapy for multiple myeloma, which is the c of B cells in the blood. In addition, Dr. Nicholas Gonzalez, affiliated with Cornell University Medical School in New York, has worked tirelessly to show that proteolytic enzymes are effective in the clinical management of pancreatic c. In recognition of his painstaking work, Dr. Gonzalez has been awarded a research grant by the National C Institute to carry out a clinical trial. Undoubtedly, the work of scores of scientists and physicians over the decades deserves recognition, which has made this sea change possible. By the same token, however, it is also a testament to the insights, vision, and belief that Dr. Wolf had in his work.

Technology and Entrepreneurism

The story of science is replete with coincidences, which make things turn for the better. Dr. Karl Ransberger's association with Drs. Wolf and Benitez was one such event that ushered in the era of systemic enzyme therapy. In addition to being an accomplished researcher, Dr. Ransberger also had an entrepreneurial streak, which he used to make systemic enzyme the world's premier preparation, and maintains even today to chart new trails in enzyme therapy. Professional association between Dr. Ransberger and his mentor Dr. Wolf soon develop into business partnership and life-long friendship. When Drs. Ransberger and Wolf decided to move back to Germany with this truly innovative enzyme preparation for its time, in recognition of the work by Drs. Wolf and Benitez, it was given the name WoBeEnzym.. Over the past 45 years, Wobenzym has become a household name in Germany in particular but also in other European countries as well. Furthermore, Wobenzym is recognized all over the world with MUCOS Pharma's subsidiaries in countries such as Argentina, Mexico, Spain, Czech Republic, India, Pakistan, Korea, New Zealand and, of course, the United States.

Technology Development

Before this success became possible, numerous scientific and technical challenges had to be met and overcome. One of the major challenges was to preserve the integrity of the enzymes during the manufacturing process. Enzymes are notoriously fragile: Exposure to heat deactivates them. In addition, even the slightest exposure to moisture prods them to chewing themselves up. That is the nature of the beasts. Enzymes contained in Wobenzym are proteins, and proteolytic enzymes do break themselves down (auto-proteolysis) -- quite like the snake that cannibalizes itself by chewing on its own tail.

That was the challenge that faced Dr. Ransberger in the early 1960s: Namely, how to stabilize the enzymes while purifying them in large quantities with the highest potency. Purity and potency of enzymes is absolutely necessary to be effective. Dr. Ransberger was at the forefront of the efforts to develop the technology to achieve these goals. Under his leadership, scientists and researchers developed techniques that ensured that the enzymes are purified to the highest possible degree and are stabilized such that their biological activity is retained.

The next challenge, of course, was to the manufacturing of enzymes in the tablet form. Making tablets during the manufacturing process generates considerable heat. Being heat-sensitive as the enzymes are, it was absolutely necessary to keep the temperature down in order for enzymes to remain active. With remarkable ingenuity, Dr. Ransberger and his team optimized manufacturing conditions to cool down the tableting machinery and equipment to maintain exactly the correct temperatures throughout the manufacturing process for enzymes to remain "alive" and biologically active.

Like his mentor Dr. Wolf, the driving force for Dr. Ransberger's hard work, dedication and commitment was to help people. That is the reason, the innovations at MUCOS did not stop in the 1960s. For example, today, MUCOS Pharma isolates chymotrypsin, one of the enzymes in Wobenzym, by state-of-the-art column chromatography. Over the years, breakthrough thinking combined with a burning desire to find safe and wholesome healthcare solutions has been the hallmark of MUCOS' mission. It is the result of Dr. Ransberger's lifelong focus, scientific and technological expertise and a businessman's acumen that today Wobenzym is world's most-renowned enzyme preparation.

By persistent efforts, extensive research and development, and innovative technology, Dr. Ransberger found a way to stabilize enzymes to withstand the harsh processing during manufacturing. It is this patented technology that MUCOS Pharma uses to not only extract enzymes from their sources but also to stabilize them such that enzymes retain their full biological activity. Without maximal activity, an enzyme preparation is not what it is cut out to be. That is the reason, MUCOS Pharma, and its North American corporate partner, Marlyn Nutraceuticals, stands foursquare behind Wobenzym.

Enzymes facilitate the smooth commerce of the bodily functions. They are an indispensable part of human health and disease. For good reason, then, in 1966, the editor of the Scottish Medical Journal editorialized thus in 1966: "Probably nearly half of our daily production of protein in the body consists of enzymes. Indeed, each of us, as with all living organisms, could be regarded as an orderly succession of enzymatic reactions."
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All information on this site is provided for informational purposes only! By no means is any information presented herein intended to substitute for the advice provided to you by your own physician or health care provider. You should not use any information contained in our site to self-diagnose or personally treat any medical condition or disease or prescribe any medication. If you have or suspect you have a medical condition you are urged to contact your personal health care provider immediately. All health supplements or products purchased in this site contain clearly labeled product packaging, which must be read to ensure proper use. All information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.

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