It's not uncommon for a prescription drug to take 10 years to go through the lengthy clinical trials and FDA approval process before it's allowed to enter the market. By the time doctors are educated on it, the drug's already old.

We have entered a digital era. Just two years ago everybody was using 28.8K modems.

Today, nearly half of the American families have high speed Internet connections. Technology leaps forward. We just can't wait for 10 or 20 years for a new drug to come out only to find that it is an old 28.8K modem.

In many cases, supplements and alternative therapies have become the mainstream treatment measures for diseases. And to a large extent, they are the ones who represent the most current and the most advanced medicine technologies.

Drugs such as paracetamol, codeine and tramadol are pain relievers. COX-based anti-inflammatory medications are used in osteoarthritis to treat symptoms of stiffness. They are very good for controlling the stiffness associated with osteoarthritis, and have brought relief to osteoarthritis sufferers for decades - but at the cost of unwanted side effects, particularly on the stomach.

The injection of a corticosteroid (e.g., methylprednisolone) into a joint can be a useful way to settle down an acute inflammatory flare of osteoarthritis. Local anaesthetic is usually also injected. Although many people like to have their osteoarthritis treated this way, studies have not confirmed any long-term benefit. Another type of injection used for osteoarthritis is hyaluronan. This is like a synthetic joint fluid and involves having three injections spaced one week apart. Studies suggest that benefits may last about eight months, but many doctors remain skeptical. 

No FDA-approved drugs currently available can reverse changes of bones and joints in the late stages of osteoarthritis. Current research on osteoarthritis is focused on developing new ways of improving the body's natural repair mechanisms and ways to prevent cartilage breakdown. EZorb Calcium is the result of such research effort.

 

EZorb Calcium enhances the body's cartilage repair function and stimulates collagen production. It also optimizes the cartilage matrix and is aimed at permanent osteoarthritis pain relief. Taken initially with pain relievers or anti-inflammatory medication it is the best non-drug alternative to improve mobility and quality of joints, and to reduce disability.* 

Collagen is a type of protein. Protein is abundant in the human body, as it is with all living creatures. In humans different systems and parts of the body require different proteins that have a variety of functions. It is these "functional proteins" that are the essence of life. 

It is easier to understand collagen if we have some knowledge of the role of proteins within the body and what a protein is made from. Proteins are used by the body for a whole host of things, e.g. within blood (for carrying molecules and for clotting), for digestion (enzymes are proteins), for movement (muscle), etc. etc. One other major role of proteins is that of "structural proteins", i.e. those proteins that contribute to and sustain the integrity of the human structure. Collagen is a structural protein and in this sense is both "functional" and "structural". 

Hold this thought for a moment while we look at what makes a protein. Proteins are constructed from biological building blocks called amino acids. There are about 20 amino acids that occur in nature and different proteins are built from some or all of these. By using different numbers of amino acids and by altering the relative sequence of them it is possible to make unique proteins, with unique qualities. 

Collagen is unique and also has two amino acids not found in other biological proteins; they are hydroxylated versions of known amino acids that confer special properties. 

Collagen is found in a number of tissues, in various sub forms, but is particularly abundant within and around joints. Tendon and cartilage owe much of their desirable properties to collagen. Collagen containing structures, such as the ones mentioned, are prone to wear and tear in the body. 

Indeed, they are in a constant state of turnover, as with most tissues, but have the disadvantage of having a poor blood supply (this does not favor ease of repair). Due to the demands upon the collagen containing structures (movement and weight bearing) and their slower ability to repair it is vital that we optimize the conditions for helping to maintain joint mobility.  

Bones with sufficient collagen composition are steels that are both strong and elastic. Bones with low level of collagen composition are brittle wood that are easily broken. Prescription drugs for osteoporosis slow down loss of bone mass by suppressing bone metabolism. The dead bone mass and collagen "saved" by the drugs take up all the space that would have been filled up by new bone mass and collagen. That's why we've seen so many reports complaining that osteoporosis drugs such as Fosamax, Actonel and Evista made bones brittle, and that people who were treated with them tend to suffer more from bone fractures. 

Wear and tear of joint cartilage is the major cause of osteoarthritis. Joint cartilage is 95% built with collagen. The more collagen you have in the joints the less chance you will develop osteoarthritis. 

If we consider all the above points, what we need is a way of speeding up collagen production so as to help the repair processes of collagen structures in a safe and preferably natural way. 

Causes of Osteoarthritis

Nearly half of all Americans older than 60 develop osteoarthritis and most people older than 80 will develop it. The percentage of people with osteoarthritis in Canada is even higher. But joints don't just wear out with age. Researchers now recognize that several factors lead to the development of osteoarthritis rather than one single factor. These are: biological Factors, age, joint damage by injury or by chronic obesity, and heredity.   

Interestingly all of those factors eventually lead to osteoarthritis through weakening bone and joint metabolism.

 

Although it seems that only those "over the hill" get osteoarthritis, it has been detected in people before they reach 21. Osteoarthritis may be more common in older people, but age is definitely only one of the causes.

 

An injury such as a fracture or torn cartilage may result in osteoarthritis later in life. It may follow unusual or prolonged strain on a joint either in work or sport. People who constantly stress their joints are at particular risk of getting osteoarthritis, e.g., bus drivers, coal miners and foundry workers. But long distance runners who are trained in avoiding and recovering from injury are not more likely to develop osteoarthritis.

 

Being overweight for a long period is also considered to speed up the process. People who are obese may be more likely to develop osteoarthritis but the jury is still out on this exact link.

 

Too much weight leads to increased stress on weight bearing joints such as the knees, hips and lower spine and people who are overweight are also more likely to develop osteoarthritis in their fingers and hands.

 

Some forms of osteoarthritis do run in families, especially those that affect the small joints of fingers. But in general, heredity is not a major reason for osteoarthritis.

 

In some people, osteoarthritis may be triggered by another disease, for example, Paget's disease.

 

Although the main cause of osteoarthritis is known to be weakened bone, joint and muscle metabolism, the precise mechanisms leading to osteoarthritis are still unknown and research is continuing. Research is underway regarding cells within cartilage that break down, leading to osteoarthritis.

 

Osteoarthritis is not caused by bacteria or poisons in the blood, acids in the body, diet deficiencies or excesses, gland abnormalities, the weather, exercise or sudden shock, although some of these may influence the pain.

 

Normally, joints have such a low friction level that they don't wear out unless they are used excessively or are injured. When bone and joint metabolism slows down, even at a low friction level the joint cartilage wears out easily.

 

Osteoarthritis probably begins most often with an abnormality of the cells that synthesize the components of cartilage, such as collagen (a tough, fibrous protein in connective tissue) and proteoglycans (substances that provide the cartilage's resilience).

 

Next, the cartilage may grow too much, but it eventually thins and develops cracks on the surface. Tiny cavities form in the marrow of the bone beneath the cartilage, weakening the bone.

 

Bone can overgrow at the edges of the joint, producing bone spurs (osteophytes), which can be seen and felt. These bone spurs may interfere with normal joint function, causing pain.

 

Ultimately, the smooth, slippery surface of the cartilage becomes rough and pitted, so that the joint can no longer move smoothly. All the components of joints fail in various ways.

 

It's not uncommon for people who have developed osteoarthritis to also display symptoms of osteoporosis, bone spurs or fibromyalgia. In fact, many bone and joint related problems can be traced down to a common problem: weakened bone and joint metabolism. When you grow older your bone, joint and metabolism slows down naturally. When that happens you'll start to experience all sorts of problems with bone, joint and muscle. EZorb is the only product that has successfully addressed all those problems from the source - by raising the level of bone, joint and muscle metabolism. 

• Use straight-backed chairs, firm mattresses or bed boards. Excessively soft chairs, recliners, mattresses and car seats may worsen symptoms.
• Maintain ordinary daily activities, your job and a functional and independent role in your family.
• Heat treatment can help, e.g., dipping a sore hand in a paraffin bath; or soaking in hot or warm baths can soothe.
• Massage by trained therapists, traction and deep heat treatment with diathermy or ultrasound may help relieve osteoarthritis in your neck. Protect joints with, for example, splints on fingers during painful jobs.
• For osteoarthritis of the spine, specific exercises sometimes help, and back supports or braces may be needed when problems are severe.
• Appropriate exercise for stretching and strengthening helps keep cartilage healthy, and increases the range of movement in a stiffening joint. It also strengthens surrounding muscle. Exercise must be balanced by rest of painful joints. But immobilizing a joint is more likely to worsen osteoarthritis than improve it.

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