After almost two decades of intensive study, Resveratrol has an exciting spectrum of benefits:

• Potent antioxidant, working through multiple pathways

• Anti-inflammatory, and analgesic-reduces pain

• Counters metabolic activation of chemicals to more toxic forms

• Blocks new blood vessels that may enable tumor metastasis

• Promotes DNA repair, delays self-destruction in damaged cells (apoptosis)

• Potent protectant for the brain, heart, and other organs

• Down-regulates C-reactive protein (CRP), cardiovascular risk indicator

• Blocks harmful effects of high-calorie diet on healthy aging

• Extends lifespan in lower animals and in mice fed high-calorie diets

Extending life and improving its quality has been the quest of science for centuries. The most promising discovery is not a wonder drug, but a polyphenal nutrient called resveratrol, which is found in plants and the skin and seeds of grapes. Researchers in prestigious institutions worldwide are now sharply focused on resveratrol, and studies have shown that it can selectively influence gene expressions in patterns that enhance healthy life processes and significantly impact those associated with aging. 

The Breakthrough Harvard Study

Landmark research published in 2006 in the prestigious journal Nature by researchers based at Harvard Medical School, the U.S. government's National Institute of Aging, reported that resveratrol improved the health and survival of mice maintained from middle age into old age on a high-calorie diet. After a year of treatment, the mice on a high calorie diet without resveratrol were dying significantly earlier than those receiving resveratrol. Mice given resveratrol were living as long as the standard-diet (control) group. The mice on a high calorie diet developed  blood sugar and insulin abnormalities, but resveratrol supported normal blood sugar metabolism as a component of the diet. In humans, high calorie diets rich in total fat may lead to changes in blood sugar regulation, cardiovascular health and liver function. Resveratrol may be important for supporting healthy blood sugar metabolism, promoting cardiovascular function and optimizing liver health in conjunction with healthy diet and lifestyle.

Best Resveratrol Features ResVinol-25

A Superior Form of Resveratrol 

Best Resveratrol features ResVinol-25, a proprietary extract providing concentrated levels of polyphenols and trans-resveratrol from red wine matrix and the root of the Japanese knotweed plant. Resveratrol exists in both trans- and cis-forms; however, research suggests that only the trans- form has considerable biological activity.

 

ResVinol-25 is a high-quality extract subjected to rigorous ProfileProven analytical and quality assurance procedures designed to ensure the potency and purity of the extract.  

A Multitude or Important Benefits

In animal and human tissue studies, resveratrol showed an ability to support the normal, healthy function of blood vessel linings. Resveratrol is also one of the few nutrients that promotes a healthy inflammatory response, balancing this important immune mechanism. Able to cross the blood-brain barrier, resveratrol seems to have strong neuro-protective effects, even at low doses, and can protect DNA at a fundamental level, in binding directly with the DNA strands. This ability could explain its capacity to regulate the normal growth cycle of cells, promoting their healthy function. Resveratrol suppresses free radical activity, promotes healthy immunity, and may enhance the body's ability to deal with stress.

A Must-Take Nutrient For Young and Old

Best Resveratrol is not just for the old or the middle-aged. Resveratrol is now entering human clinical trials that will help determine its utility for weight management and promoting healthy blood sugar metabolism in conjunction with healthy diet and lifestyle, areas in which old and young people often require additional nutritional support.

 

Based on animal research, it seems likely that to be assured of the full range of healthy aging benefits, humans probably need to start on resveratrol before reaching middle age. Always Ask for the Best, Doctor's Best. Unmatched Quality, Purity and Value.

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Best Resveratrol featuring ResVinol-25 is a science-based formulation, manufactured with a trademarked ingredient of unsurpassed quality and purity, delivered at clinically-proven potency.

Resveratrol:
Unique Nutrient for Extending Health Into Old Age
by Parris M. Kidd, PhD 

 

Living a very long life with youthful vitality is a universal human longing. Now a nutrient is available with real promise to deliver this reality. The nutrient is RESVERATROL (RES-VER-A- TROL).

But another, extremely rare property elevates resveratrol into a category all its own-this simple nutrient is a master gene regulator.

In 2006, a landmark research report was published in the prestigious journal Nature, by 27 researchers based at Harvard Medical School, the U.S. Government's National Institute of Aging, and other internationally recognized institutions on three continents. The study reported that resveratrol improved the health and survival of mice maintained from middle age into old age on a high-calorie diet.

 

Until resveratrol, the only intervention proven to extend lifespan was drastic CR-Iowering of caloric intake by at least 40 percent, while maintaining nutrient intake to avoid malnutrition. Though successful with lab animals, with humans such discipline is rarely achieved. The Nature mouse study tested the hypothesis that resveratrol might provide the benefits of CR without reducing calorie intake.

 

Groups of mice were started on the high-calorie diet, or the high-calorie diet plus resveratrol, at age 12 months (middle age). A control group received the standard, healthy mouse diet. After 12 months of treatment, the high-calorie mice without resveratrol were dying significantly earlier than those receiving resveratrol. The resveratrol mice were living as long as the standard-diet group. The hypothesis proved correct-resveratrol protected mice against the harmful effects of a high-calorie diet.

Improved Blood Sugar and Insulin Sensitivity

In humans, high-calorie diets damage blood sugar control and insulin regulation, which can lead to diabetes, cardiovascular disease, and deadly liver disease. The high-calorie mice developed blood sugar and insulin abnormalities but resveratrol again gave protection. In resveratrol-treated mice the gene AMPK was activated. This gene is known to manage insulin and is also up-regulated by CR.

The HC mice without resveratrol developed greatly increased liver size and weight, with liver cell damage and fat accumulation. They also displayed subtle pancreatic damage. Giving resveratrol protected against all these negative changes. In addition, resveratrol protected the heart against inflammatory damage and fat accumulation, and improved aorta wall structure.

CR (and exercise, incidentally) can increase the liver's density of mitochondria, the cell compartments that generate most of our energy. In this Nature study resveratrol also increased the liver's mitochondria density. Biochemical analysis linked resveratrol to increased enzyme activity from SIRT1, and from other genes probably activated by SIRT1.

 

Sophisticated gene monitoring revealed also that resveratrol changed the "expression" (on or off) of 782 mouse genes, including down-regulating three genes that can transform various chemicals to carcinogens. Resveratrol blocked the harmful high-calorie effects in 144 of the total 153 pathways found to be altered. Some 19 pathways were identified in which resveratrol's gene regulatory benefits paralleled those from CR.

Those mice on high calories that received resveratrol showed improved function as they aged. On a test of balance and motor coordination, these mice steadily improved their motor skills overtime. This positive effect resembled the improvement of motor activity that accompanies resveratrol's lifespan extension in the fish Nothobranchius.

 

As the Nature study findings suggest, resveratrol likely enhances life quality by influencing many genes, in addition to SIRT1 and AMPK. SIRT1 itself influences many other genes , and through them a variety of life processes. Resveratrol additionally influences genes for quinone reductase 2 and other enzymes that regulate energetics; SOD and other antioxidant genes; NF-kappa B and other genes that control apoptosis and cell survival; genes that control cell proliferation; and numerous others.

Resveratrol has displayed circulatory benefits in various animal "models" and in humans. In the Nature mouse study, it blocked high calorie damage to the heart and aorta. In other studies with animal and human tissues, resveratrol protected the blood vessel linings against atherosclerotic damage and against increased platelet aggregation, as can result from cigarette smoking, abnormal blood cholesterol, or homocysteine elevation. It also promoted healthy tone in the small blood vessels , perhaps through improved nitric oxide homeostasis.

 

Resveratrol is one of the few nutrients that can lower CRP, a proven risk factor for heart attack and stroke. In experimental animals it protected the heart against oxygen deprivation. In a clinical trial with type 2 diabetic subjects who had recently suffered heart attack (myocardial ischemia), resveratrol improved the heart's left ventricle function.

As with the heart, resveratrol also protects the brain against damage caused by ischemia (including stroke). This small molecule seems able to readily cross the blood-brain barrier, and can protect against ischemic damage to the hippocampus, the brain region that initiates memories. Resveratrol seems to have strong neuro-protective effects, even at low doses. Currently two clinical trials are pending against Alzheimer's disease.

Human DNA is constantly exposed to potentially destructive influences, both from outside and inside the body. On average, each human cell takes at least 10,000 hits to its DNA each day, anyone of which could cause a harmful gene mutation. Resveratrol protects DNA at a fundamental level: direct binding with the DNA strands. This ability to come into close proximity with DNA could explain resveratrol's capacities to block abnormal cell growth transformation and the premature cell aging or cell death scenarios associated with DNA damage.

 

Above the level of DNA, resveratrol can up-regulate the antioxidant defenses as it suppresses "free radical" activity. It boosts liver detoxification activity via the P450 enzyme system. Nor are its organ protective effects limited to the heart and brain. Resveratrol can block experimental injury to the intestine, colon, liver, kidneys, lungs, joints, and spinal cord, and protect against hearing loss.

Resveratrol is also a potent anti-inflammatory nutrient. It is a powerful inhibitor of cyclooxygenase-1 (COX-1), an enzyme that can promote inflammation especially in subjects with poor omega-3 fatty acid intakes. But resveratrol does not appreciably block COX-2 and so has none of the liability of COX-inhibitor pharmaceuticals.

Besides counteracting pro-inflammatory reactions, resveratrol promotes healthy immunity. It can correct the immune suppression that alcohol can cause, and protects mice from infection by herpes simplex viruses 1 and 2.

A new scientific paradigm of aging has emerged, one that recognizes practical possibility for extending the human lifespan in our lifetime. The most promising vehicle for human lifespan extension is not a wonder drug, but the wondrous nutrient resveratrol. Academic and private sector researchers in top-class institutions worldwide are sharply focused on resveratrol for a dazzling variety of health applications.

But resveratrol is not just for the old or the middle-aged. It is now entering Clinical Trials to combat obesity, insulin resistance, and diabetes, conditions that increasingly afflict young people. And the animal research suggests that to be assured of "anti-aging" benefit humans probably need to start on resveratrol before reaching middle age.

Young persons and others of any age also could investigate resveratrol for cancer prevention. Three of the pending clinical trials relate to prevention of cancers-melanoma, colon, and other solid tumors. Three others are targeted at cancer treatment-colon, rectal, and lymphoma. Resveratrol absorption has been studied in humans, but much about its human metabolism remains unanswered. But in most of the animal studies, the effective intakes were within a range available from well-formulated resveratrol supplements (100 mg per day and more). In the landmark Nature mouse study, as the best example, using a reliable calculation the effective resveratrol dose translates to 145 per day for a 180-pound adult human. The amount of red wine needed to provide this amount of resveratrol wouId enter the zone of alcohol toxicity. For full and reliable benefit, it is best to take a potent resveratrol supplement.

Resveratrol is certainly not a panacea-already the most challenging of the clinical trials plan to employ it in combination with other nutrients. But this unique nutrient has sparked new optimism: that even our DNA can benefit from rational nutritional intervention. The rapidly-expanding knowledge base on resveratrol supports the proposition that it can help the human body attain excellent health and maintain it into a ripe old age.
Parris M_ Kidd, Ph.D.